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Zoledronic Acid Injection (Zuolailinsuan Zhusheye)
Please peruse the instructions carefully before using and following the advice of a physician.
[Drug Name]
Common Name:  Zoledronic Acid Injection(Zuolailinsuan Zhusheye) 
Trade Name: Tianqing Yitai
English Name: Zoledronic Acid Injection
Chinese Pinyin: Zuolailinsuan Zhusheye
Ostealgia caused by osteolytic bone metastases of malignant tumors. 
5ml: 4mg (by anhydrous Zoledronic Acid) 
[Usage and Dosage]
Intravenous Drip. For adults, 4mg per time, intravenous drip after diluted with 100ml of 10.9% sodium chloride injection or 5% glucose injection; while time for intravenous drip shall be not less than 15 minutes. Drug administration shall be carried out once 3-4 weeks or follow the medical advice. 
[Adverse Reaction]
The most common adverse reaction of this drug is fever; other adverse reactions are mainly as follows: 
General reaction: hypodynamia, thoracalgia, leg oedema and conjunctivitis; 
Digestive system: nausea, vomiting, constipation, diarrhea, bellyache, dysphagia and anorexia; 
Cardiovascular system: hypotension;
Blood and lymphatic system: anemia, hypokalemia, hypomagnesemia, hypophosphatemia, hypocalcemia, granulocytopenia, thrombocytopenia and pancytopenia;
Muscle and bones: ostealgia, arthralgia and courbature; 
Kidneys: The value of creatinine in blood serum may increase (depend on the time of drug administration); 
Nervous system: insomnia, anxiety, excitement, headache and hypnesthesia; 
Respiratory system: dyspnoea, coughing and pleural effusion; 
Infection: urinary tract infection and upper respiratory tract infection; 
Metabolic system: anorexia, weight loss and dehydration; 
Others: symptoms like those of flu, inflammation, rash and pruritus etc. on the injection position. 
The toxic and side effects of Zoledronic Acid are generally mild and transitional, therefore, in most cases, such toxic and side effects will subside automatically within 24~~28 hours, without any special treatment. 
1. This drug shall not be taken by patients allergic to this drug or other kinds of bisphosphonates drugs; 
2. This drug is not recommended for patients with serious renal insufficiency; and
3. This drug shall not be taken by pregnant or lactant women.